evaluation of the anti–depressant activity of myristica fragrans (nutmeg) in male rats

objective: the present study was undertaken to evaluate anti-depressant activity of myristica fragrans(ms). materials and methods: male wistar rats were subjected to imipramine and herbal extract ofms for their antidepressant activity using forced swimming test (fst), reserpine reversal test (rrt), haloperidol-induced catalepsy (hic), and pentobarbitone sleeping time (pst). results: administration of ms and imipramine revealed a statistically significant reduction in immobility time in fst, rrt, and protection against hic, compared to the control group. however, there was no significant potentiation of pst. conclusion: our study demonstrated the potential antidepressant activity of ms.